Diphu Medical College was established in the year 2011. The name of Diphu Medical College during that time was Assam Hills Medical College and Research Institute (AHMC&RI). Later the name of Assam Hills Medical College and Research Institute(AHMC&RI) was changed to Diphu Medical College in the interest of the general public. The college is mainly opened to serve the people of Karbi Anglong district and other neighbouring districts.

The construction was initiated by laying the foundation stone on 19 January 2011. In 2017, The existing work of the college was enhanced from 156.55 crores to 209 Crores. 

The college has the facilities like 300 beds, a modern library, an air-conditioned Lecture hall. The college has a current intake of 100 undergraduate students from the academic year 2020-21.